参考资料:
[1]Partridge, Linda et al. “The quest to slow ageing through drug discovery.” Nature reviews. Drug discovery vol. 19,8 (上年): 513-532. doi:10.1038/s41573-020-0067-7
[2]López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013 Jun 6;153(6):1194-217. doi: 10.1016/j.cell.2013.05.039. PM发布者会员账号: 23746838; PMC发布者会员账号: PMC3836174.
[3]Maglione, M., Kochlamazashvili, G., Eisenberg, T. et al. Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses. Sci Rep 9, 19616 (前年).
[4]Eisenberg, T., Knauer, H., Schauer, A. et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11, 1305–1314 (2009).
[5]Büttner, Sabrina, Filomena Broeskamp, Cornelia Sommer, Maria E. Markaki, Lukas Habernig, Ali Alavian-Ghavanini, Didac Carmona-Gutierrez, Tobias Eisenberg, Eva Michael, Guido Kroemer, Nektarios Tavernarakis, Stephan J. Sigrist and Frank Madeo. “Spermidine protects against α-synuclein neurotoxicity.” Cell Cycle 13 (2014): 3903 - 3908.
[6]Eisenberg T, Knauer H, Schauer A, et al. Induction of autophagy by spermidine promotes longevity[J]. Nature cell biology, 2009, 11(11): 1305.
[7]K. Soda, Y. Dobashi, Y. Kano, S. Tsujinaka, F. Konishi, Polyamine-rich food decreases age-associated pathology and mortality in aged mice. Exp. Gerontol. 44, 727–732 (2009).
[8]T. Yamamoto et al., The natural polyamines spermidine and spermine prevent bone loss through preferential disruption of osteoclastic activation in ovariectomized mice. Br. J. Pharmacol. 166, 1084–1096 (2012).
[9]R. Kibe et al., Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice. Sci. Rep. 4, 4548 (2014).
[10]S. Pucciarelli et al., Spermidine and spermine are enriched in whole blood of nona/centenarians. Rejuvenation Res. 15, 590–595 (2012).